“Very rarely do bidding wars erupt over houses that back up to the interstate….”
In other words….beware the bad lot.
If a house backs to a roadway or power lines (or strip mall or railroad track or BMP….) be VERY careful about building your house there. Typically, the builder or developer has not discounted the lot enough to account for the negative impact on the final value. Another thing to keep in mind is that the lot that backs up to that little country road now may be backing up to the new 4 lane 50 mile per hour turnpike in 10-15 years.
Use your common sense and see what the road connects. Odds are, it is going to get busier.